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KMID : 0361020080510010016
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Korean Journal of Otolaryngology - Head and Neck Surgery
2008 Volume.51 No. 1 p.16 ~ p.21
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Expression Patterns of Erythropoietin and Erythropoietin Receptor in the Spiral Ganglion of Guinea Pig after Noise Exposure
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Kim Dong-Hyun
Park Yong-Ho
Kim Ah-Young
Park Jae-Yong
Han Wook-Kyoung
Choi Jin-Woong
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Abstract
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Background & Objectives: Erythropoietin (EPO) is produced in the kidney and locally in the CNS and acts through binding to erythropoietin receptor (EPO-R). Apart from playing an essential role in erythropoiesis, recent research has shown that EPO has neurotrophic and neuroprotective functions in the CNS and found EPO and EPO-R in the inner ear. The aim of this study is to investigate distribution and expression of EPO and EPO-R in the inner ear after noise exposure.
Materials & Method: Normal guinea pigs were exposed to noise. Ten of them were sacrificed at 1 hour of the noise exposure (group B) and another 10 animals were sacrificed at day 7 (group C). Four were normal controls that were not exposed to noise (Group A). Auditory function was evaluated by ABR for 7 days. Noise-induced morphological changes of cochlea were studied by phalloidin stain. The expression of EPO and EPO-R was examined by immunofluorescence.
Results: The hearing threshold shift reached a level of 40 dB SPL at 8 kHz at day 1 after noise exposure and underwent a partial recovery at day 7. Increased expression of EPO and EPO-R were observed at the level of spiral ganglion cells in the noise-exposed animals.
Conclusions: It is suggested that noise exposure affects the distribution and expression of EPO and EPO-R in the inner ear.
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KEYWORD
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Noise, Spiral ganglion, Erythropoietin, Erythropoietin receptor
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